Drug

Daily Dose

Adverse Effects

Comments

Formulations

Aripiprazole^OL

5–15 mg

Mild sedation, mild hypotension

Warning about increased cerebrovascular events in dementia, possible hyperglycemia

Tablet, liquid concentrate

Clozapine^OL

12.5–200 mg

Sedation, hypotension, anticholinergic effects, agranulocytosis

Weekly CBCs required, poorly tolerated by older adults, reserved for treatment of refractory cases, warning about hyperglycemia

Tablet, rapidly dissolving tablet

Olanzapine^OL

2.5–10 mg

Sedation, falls, gait disturbance

Warning about hyperglycemia and cerebrovascular events in patients with dementia

Tablet, rapidly dissolving tablet, IM injection

Quetiapine^OL

25–200 mg

Sedation, hypotension

Warning about hyperglycemia, ophthalmologic exam recommended every 6 months

Tablet

Risperidone^OL

0.5–2 mg

Sedation, hypotension, EPS with doses > 1 mg/day

Warning about cerebrovascular events in patients with dementia, hyperglycemia warning

Tablet, rapidly dissolving tablet, liquid concentrate, depot IM injection

Ziprasidone^OL

40–160 mg

Higher risk of QTc prolongation

Warning regarding increased QTc prolongation, possible hyperglycemia

Little published information on use in older adults

Capsule, IM injection