Study End Point

Effect of Testosterone

Lean body mass

Increased

Fat mass

Decreased

Bone mineral density

Variable

Strength

Variable

Improved strength and performance of some functional tasks in some studies

Sexual function

Variable

Activation in sexual behavior and increased libido (most consistent findings)

Mood

Variable

Mood, subjective well-being improved (in some studies)

Cognitive

Some cognitive domains improved

Worsened effect of practice on verbal fluency

Lipid profile

Decreased total, LDL cholesterol

HDL cholesterol unchanged

Coronary heart disease

In men with established disease, improved ECG evidence of exercise-induced coronary ischemia (in most studies)

Variable effect on angina pectoris

Prostate

PSA increased slightly in many patients

No effect on voiding symptoms, prostate examination

Hematocrit

Increased 2.5% to 5% versus baseline

Erythrocytosis developed in 6% to 25% of subjects

Long-term clinical outcomes

Unknown